Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.

Research Base: Children's Oncology Group
NCT ID: NCT03057054
NCI Protocol Number: COG-ACCL1633
Status: Recruiting

For more information see


Allogeneic Hematopoietic Stem Cell Transplantation; Laboratory Biomarker Analysis; Lactobacillus plantarum strain 299; Lactobacillus plantarum strain 299v; Placebo


Childhood Malignant Neoplasm, Hematopoietic Cell Transplantation Recipient

Trial Type

Supportive Care/Symptom Management/PROs

See a list of participating sites on