Exercise and Low-Dose Ibuprofen for Cognitive Impairment in Colorectal Cancer Patients Receiving Chemotherapy

This randomized phase II trial studies how well exercise and low-dose ibuprofen in improving cognitive impairment in patients with colorectal cancer that has not spread to other places in the body who are receiving chemotherapy. Anti-inflammatory agents, such as ibuprofen, may slow the decline of cognitive processes and diseases involving the brain. Exercise may also help alleviating cognitive difficulties during chemotherapy.

Research Base: Gary Morrow
NCT ID: NCT03186638
NCI Protocol Number: URCC-16092
Status: Recruiting

For more information see ClinicalTrials.gov


Exercise Intervention; Ibuprofen; Informational Intervention; Laboratory Biomarker Analysis; Placebo; Questionnaire Administration


Cognitive Impairment, Stage 0 Colorectal Cancer, Stage I Colorectal Cancer, Stage II Colorectal Cancer, Stage IIA Colorectal Cancer, Stage IIB Colorectal Cancer, Stage IIC Colorectal Cancer, Stage III Colorectal Cancer, Stage IIIA Colorectal Cancer, Stage IIIB Colorectal Cancer, Stage IIIC Colorectal Cancer

Trial Type

Supportive Care/Symptom Management/PROs

See a list of participating sites on ClinicalTrials.gov