Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy
This randomized phase III trial studies how well olanzapine with or without fosaprepitant work in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting. Olanzapine and fosaprepitant dimeglumine may help control nausea and vomiting in patients during chemotherapy. Olanzapine is usually given in combination with other drugs, including fosaprepitant dimeglumine. It is not yet known if olanzapine when given with other drugs, is still effective without using fosaprepitant dimeglumine for controlling nausea and vomiting.
Research Base: Alliance for Clinical Trials in Oncology
NCT ID: NCT03578081
NCI Protocol Number: A221602
For more information see ClinicalTrials.gov
Palonosetron Hydrochloride; Ondansetron Hydrochloride; Dexamethasone; Fosaprepitant Dimeglumine; Olanzapine; Placebo
Supportive Care/Symptom Management/PROs