Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer
This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent peripheral neuropathy.
Research Base: Alliance for Clinical Trials in Oncology
NCT ID: NCT04137107
NCI Protocol Number: A221805
Status: Recruiting
For more information see ClinicalTrials.gov
Interventions
- Oxaliplatin
- Duloxetine Hydrochloride
- Duloxetine
- Quality-of-Life Assessment
- Questionnaire Administration
- Placebo
Condition
Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8
Trial Type
Supportive Care/Symptom Management/PROs
See a list of participating sites on ClinicalTrials.gov